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- Ross R McMullan, Daniel F McAuley, Cecilia M O'Kane, and Jonathan A Silversides.
- Wellcome-Wolfson Institute for Experimental Medicine, Queen's University of Belfast, Lisburn Road, Belfast, BT9 7BL, UK. rmcmullan07@qub.ac.uk.
- Crit Care. 2024 Mar 23; 28 (1): 9797.
AbstractSepsis is a life-threatening condition characterised by endothelial barrier dysfunction and impairment of normal microcirculatory function, resulting in a state of hypoperfusion and tissue oedema. No specific pharmacological therapies are currently used to attenuate microvascular injury. Given the prominent role of endothelial breakdown and microcirculatory dysfunction in sepsis, there is a need for effective strategies to protect the endothelium. In this review we will discuss key mechanisms and putative therapeutic agents relevant to endothelial barrier function.© 2024. The Author(s).
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