• Run Zhou Ye, Kirill Lipatov, Daniel Diedrich, Anirban Bhattacharyya, Bradley J Erickson, Brian W Pickering, and Vitaly Herasevich.
• Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905, USA.; Division of Endocrinology, Department of Medicine, Centre de Recherche du CHUS, Sherbrooke QC J1H 5N4, Canada.
• J Crit Care. 2024 Aug 1; 82: 154794154794.

ObjectiveThis study aims to design, validate and assess the accuracy a deep learning model capable of differentiation Chest X-Rays between pneumonia, acute respiratory distress syndrome (ARDS) and normal lungs.Materials And MethodsA diagnostic performance study was conducted using Chest X-Ray images from adult patients admitted to a medical intensive care unit between January 2003 and November 2014. X-ray images from 15,899 patients were assigned one of three prespecified categories: "ARDS", "Pneumonia", or "Normal".ResultsA two-step convolutional neural network (CNN) pipeline was developed and tested to distinguish between the three patterns with sensitivity ranging from 91.8% to 97.8% and specificity ranging from 96.6% to 98.8%. The CNN model was validated with a sensitivity of 96.3% and specificity of 96.6% using a previous dataset of patients with Acute Lung Injury (ALI)/ARDS.DiscussionThe results suggest that a deep learning model based on chest x-ray pattern recognition can be a useful tool in distinguishing patients with ARDS from patients with normal lungs, providing faster results than digital surveillance tools based on text reports.ConclusionA CNN-based deep learning model showed clinically significant performance, providing potential for faster ARDS identification. Future research should prospectively evaluate these tools in a clinical setting.Copyright © 2024 Elsevier Inc. All rights reserved.

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