• Theodora Papamitsou, Antonios Morsi-Yeroyannis, Anastasios Papanastasiou, Nikolaos Bakalopoulos, Eva-Maria Dietrich, Sofia Karachrysafi, Alexandros Toskas, Evangelia Mareti, Anastasia Morsi-Yeroyanni, and Antonia Sioga.
• Laboratory of Histology-Embryology, Faculty of Medicine, School of Health Sciences, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.
• Medicina (Kaunas). 2020 Jan 24; 56 (2).

Background And ObjectivesBisphosphonates (BPs) are selective inhibitors of osteoclasts, used for the treatment of bone disorders. The objective of this study is to investigate the possible effects of BPs on the tongue's mucosa.Materials And MethodsSpecimens of the tongue of 20 female 12-month old Wistar rats were taken. Ten were used as control group, while in the remaining alendronate (Fosamax, Merck) was administered per os from 13 weeks. Observation of the harvested samples was made by Transmission Electron Microscopy (TEM).ResultsIn the experimental group, focal alterations were observed to various extent in all specimens. The basement membrane was intact. Furthermore, an increase at the intercellular space was observed, predominantly at the middle layer, and the desmosomes were disorganized. In the lamina propria focal edema was observed.ConclusionsInvestigation on the effect of BPs on the tongue's mucosa through TEM hasn't been documented in the past. According to our results, BPs seem to cause mild mucosal lesions on the tongue.

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