• Minerva anestesiologica · Mar 2024

    Review

    Research progress on the association between MicroRNA and postoperative cognitive dysfunction.

    • Yuanping Zhong, Yu Zhang, and Zhaoqiong Zhu.
    • Department of Anesthesiology, Affiliated Hospital of Zunyi Medical University, Zunyi, China.
    • Minerva Anestesiol. 2024 Mar 1; 90 (3): 191199191-199.

    AbstractPostoperative cognitive dysfunction (POCD) is a significant complication following surgery. The precise mechanisms underlying POCD remain elusive, although it is speculated that they involve central nervous system inflammation, oxidative stress and cellular apoptosis. MicroRNAs (miRNAs), a class of non-coding RNAs widely distributed in eukaryotes, have been implicated in the pathogenesis of neurodegenerative disorders and could potentially impact POCD. This review explores the association between miRNAs and POCD and provides an overview of the progress of current research on miRNAs in the pathogenesis, diagnosis, and treatment of POCD.

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