• D K Luyt, J Pridgeon, J Brown, G Peek, R Firmin, and H C Pandya.
• Heartlink ECMO Centre, Glenfield Hospital, Leicester, United Kingdom.
• Acta Paediatr. 2004 Dec 1;93(12):1608-11.

ObjectiveTo describe the short-term outcome of children with meningococcal sepsis treated with extracorporeal membrane oxygenation (ECMO) in a single centre.DesignRetrospective analysis of case notes.SettingThe Heartlink ECMO Centre, Glenfield Hospital, Leicester.PatientsEleven children (8 boys) out of a total caseload of 800 patients were treated for meningococcal sepsis with ECMO.InterventionsExtracorporeal membrane oxygenation.ResultsAll children with meningococcal sepsis treated with ECMO had a Glasgow Meningococcal Septicaemia Prognostic Score (GMSPS) > or = 12 (positive predictive risk of death of approximately 90%). Five children had adult respiratory distress syndrome (ARDS) and six had refractory shock with multi-organ dysfunction syndrome (MODS) at presentation for ECMO. All five children in the ARDS group survived, four of five receiving veno-venous (VV-) ECMO therapy. In contrast, only one of six children with refractory shock with MODS survived, all of whom required veno-arterial (VA-) ECMO therapy.ConclusionsMost children with meningococcal sepsis and severe ARDS can be successfully treated with VV-ECMO. In contrast, children with refractory shock and MODS die despite treatment with VA-ECMO. This report does not resolve whether ECMO therapy offers any advantage over conventional therapy in treating severe meningococcal sepsis.

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