• Internal medicine · Nov 2024

    Case Reports

    A Cerebral Embolism Caused by a Malignant Peripheral Nerve Sheath Tumor in a Patient with Neurofibromatosis Type 1.

    • Kyosuke Matsunaga, Muneaki Kikuno, Hiroki Sakamoto, Hirofumi Okada, Takao Hashimoto, Shogo Honda, Jun Matsubayashi, Toshitaka Nagao, Yuko Yamada, Hajime Horiuchi, Masahiko Kuroda, Shigeo Murayama, Hiroo Terashi, and Michihiro Kohno.
    • Department of Neurosurgery, Tokyo Medical University Hospital, Japan.
    • Intern. Med. 2024 Nov 15; 63 (22): 308730913087-3091.

    AbstractA 31-year-old man with neurofibromatosis type 1 (NF-1) had undergone resection of a malignant peripheral nerve sheath tumor (MPNST) on the buttock 3 months previously. He subsequently underwent mechanical thrombectomy for a hyperacute left middle cerebral artery embolism. Histopathologically, the emboli comprised neurofilament-positive pleomorphic tumor cells with geographic necrosis and conspicuous mitosis and were identified as MPNST. The patient died of respiratory failure due to lung MPNST metastasis on day 15 of hospitalization. To our knowledge, this is the first report of a spontaneous cerebral embolism due to MPNST in an NF-1 patient.

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