• Chunlin Gao, Xiang Zhang, Dan Wang, Zhimin Wang, Jintao Li, and Zhongming Li.
• Medical Oncology of Yunnan Cancer Hospital, Affiliated to Kunming Medical University Experiment Center of Basic Medical Sciences, Kunming Medical University Department of Neurology, The First Affiliated Hospital of Kunming Medical University Department of Medical Imaging, The Affiliated Yan'an Hospital of Kunming Medical University The Neuroscience Institute, Basic Medical Sciences of Kunming Medical University Department of Anatomy, Basic Medical Sciences of Kunming Medical University, Kunming, Yunnan, China.
• Medicine (Baltimore). 2018 Aug 1; 97 (34): e11904e11904.

AbstractNo official spirometry reference values for Chinese are available.To establish new Chinese reference values and prediction equations for lung parameters in Chinese individuals of 10 to 81 years of age.Pulmonary functions were measured according to the American Thoracic Society criteria in 1457 subjects from the Zhejiang coastal province (China). The subjects were 10 to 81 years of age, nonsmokers, and without chronic or acute diseases. Multiple stepwise linear regression analysis was performed for each parameter against age, height, weight, and body mass index (BMI; kg/m) for males and females separately.Most lung function variables were nonlinear with age and showed a plateau in younger adults, with a decline after 31 to 35 years. All spirometric data of men were higher than those of women except breathing frequency and forced expiratory volume in 1 second (FEV1)/forced vital capacity (FVC). All measured lung function parameters were strongly correlated to age, height, weight, and BMI. The highest correlation being to height in both men and women except for tidal volume and expiratory reserve volume among women. Based on previous studies, Caucasians men from the USA and Switzerland had higher FVC and FEV1 than in the present study, but only slightly higher than American blacks, British, Pakistani, and Singapore; an inverse trend was observed for Malay and Indians. Similar relationships were observed for women. The relationship between height and lung function parameters was nonlinear, with the variance of lung function parameters increasing with increasing height. For each sex, the z scores differed significantly by BMI (P < .001).This study provides spirometry equations that can be used for Chinese individuals.

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