• Jong Seung Kim, Sam Hyun Kwon, So Eun Lee, Eun Jung Lee, and Min Hee Lee.
• Department of Otorhinolaryngology-Head and Neck Surgery, College of Medicine, Chonbuk National University Research Institute of Clinical Medicine of Chonbuk National University-Biomedical Research Institute of Chonbuk National University Hospital, Jeonju Department of Practical Music, SoHae University, Gunsan Presbyterian Medical Center, Department of Internal Medicine, Division of Allergy and Pulmonology, Jeonju, Republic of Korea.
• Medicine (Baltimore). 2018 Sep 1; 97 (36): e11832e11832.

BackgroundCorticosteroids are widely used to treat voice change after thyroidectomy. In this study, we evaluated the effect of a single dose of intravenous dexamethasone after thyroidectomy using a metaanalysis.MethodsRelevant studies were identified by searching the following databases: Medline, Embase, and Cochrane through February 2017. We followed PRISMA guidelines. The following search terms were used: "thyroidectomy," "voice," "steroid." Random-effects models were used to estimate standardized mean differences (SMDs) and 95% confidence intervals.ResultsOur search yielded one retrospective cohort study involving 122 thyroidectomy patients and 3 randomized controlled studies involving 242 thyroidectomy patients. The pooled SMD for voice quality after thyroidectomy was -0.80 (P < .05). Subgroup analysis showed significant voice quality change 1 day after administration of dexamethasone.ConclusionsSingle-dose intravenous dexamethasone after thyroidectomy significantly improves subjective voice quality on day 1. The effect was not different significantly after day 1.Level Of EvidenceLevel 2a.

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