• Ying Li, Xiao-Hui Li, Xin Huang, Lu Yin, Cheng-Xian Guo, Chang Liu, Yong-Mei He, Xing Liu, and Hong Yuan.
• aDepartment of Health Management, The Third Xiangya Hospital bHealth Management Research Center, Central South University cDepartment of Pharmacology, School of Pharmaceutical Sciences, Central South University dPreventive Medicine, Medical School of Hunan Normal University, Changsha eState Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Disease, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing fCenter of Clinical Pharmacology, The Third Xiangya Hospital, Central South University, Changsha gSecond Department of Geriatric Medicine, Aerospace Center Hospital, Beijing, P. R. China.
• Medicine (Baltimore). 2017 Nov 1; 96 (46): e8513e8513.

AbstractTraditional Chinese Medicine Constitution (TCMC) theory states that individuals with a biased TCMC are more likely to suffer from specific diseases. However, little is known regarding the influence of TCMC on susceptibility to hypertension. The aim of this study is to examine the possible relationship between TCMC and hypertension. Retrospective evaluation and observation were performed using the STROBE guidelines checklist. A large community-based cross-sectional study was conducted between 2009 and 2013 in Changsha, China. TCMC was assessed using a questionnaire that included 68 items. TCMC distributions and the associations of different TCMCs with hypertension risk were analyzed. In total, 144,439 subjects underwent evaluations of TCMC and blood pressure (BP). There were significant differences in the hypertension prevalence among the various TCMC groups (P < .01). An adjusted logistic regression model indicated that those with phlegm wetness, yin deficiency, blood stasis, or qi deficiency were more likely to have hypertension. Analysis of the clinical characteristics related to TCMC indicated that different TCMCs corresponded to different hypertension classifications using Western medicine criteria; for example, phlegm wetness with hypertension was similar to obesity-related hypertension. Our results suggest that phlegm wetness, yin deficiency, blood stasis, and qi deficiency have different effects on the prevalence of hypertension. More attention should be paid to TCMCs associated with susceptibility to hypertension, and corresponding preventive and therapeutic treatments should be developed according to different TCMCs.

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