• Qi Tang, Yuanping Wang, and Kuangyi Li.
• Guangzhou University of Chinese Medicine, Guangzhou Department of Emergency, Foshan Hospital of TCM, Affiliated Hospital of Guangzhou University of Chinese Medicine, Foshan, China.
• Medicine (Baltimore). 2018 Jul 1; 97 (29): e11559e11559.

BackgroundChronic heart failure (CHF), not only a severe personal healthy problem but also a social financial burden, has become a global health concern. Zhenwu decoction (ZWD) has been widely adopted to clinical practice for patients with CHF. It is necessary to update the researches to reevaluate the efficacy and safety of ZWD to provide the up-to-date evidence for CHF management. Therefore, we provide a protocol of systematic review regarding ZWD for CHF.MethodsThe aim of this study was to retrieve papers on the topic of ZWD treatment for CHF in the electrical databases, including PubMed, Cochrane Library, EMBASE, Chinese Biomedical database (CBM), Chinese National Knowledge Infrastructure (CNKI), Wanfang database, and Chinese Science and Technology Periodical database (VIP). The included literatures are those delivered from the time when the databases were established to May 2018. The therapeutic effects based on the mortality and the New York Heart Association (NYHA) function classification will be marked as the primary outcomes. We will use RevMan V.5.3 software to calculate the data synthesis as well as to perform meta-analysis if the results are appropriate.ResultsThe literature will provide a high-quality synthesis of current evidence of ZWD for CHF from various comprehensive assessment, including mortality, NYHA function classification, left ventricular ejection fraction, 6-minute walk test (6MWT), life quality, and adverse events.ConclusionThe systematic review will provide up-to-date evidence to assess ZWD treatment effect for patient with CHF.Prospero Registration NumberPROSPERO CRD42018083813.

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