• Ahu Pakdemirli, Caner Karaca, Tolga Sever, Ezgi Daşkin, Asim Leblebici, Türkan Yiğitbaşi, and Yasemin Başbinar.
• Department of First and Emergency Aid, Vocational School of Health Services, Dokuz Eylül University, İzmir, Turkey
• Turk J Med Sci. 2020 Feb 13; 50 (1): 271276271-276.

Background/AimNatural products are popular insights for researchers to investigate promising anti-cancer agents since some of these substances have lesser adverse effects restricting the treatment than traditional chemotherapeutic agents. A well-known monoterpene Carvacrol, widely consumed in Mediterranean cuisine and lower risks of cancer, has efficient anticancer effects. However, the mechanism of action is yet to be discovered.Materials And MethodsThe investigation aims to illuminate a new perceptive in the role of this substance on colorectal cancer treatment, by the means of differences in a well-defined range of soluble factors. Carvacrol effect on both HT-29 and HCT-116 cell lines was evaluated on proliferation and the IC50 values were calculated by the RTCA xCELLigence device. Then MAGPIX assay was performed to obtain the changes in soluble factors of the cell lines.ResultsThe Multiplexing assay suggests some of these factors were altered in favor of surviving and proliferation in aggressive cell line HCT-116 whereas they were altered against these characters in HT-29, were correlated with the increased IC50 concentration of HCT- 116 in carvacrol treatment.ConclusionThe current study indicates that differences in the levels of these soluble factors could modulate the anticancer effect related to carvacrol.This work is licensed under a Creative Commons Attribution 4.0 International License.

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