• Military medicine · Jul 2024

    Case Reports

    Occult Lung Cancer-Associated Autoimmune Encephalitis Presenting as Acute Psychosis.

    • Shelly K McCarter, K Robert Shen, and Mark E Wylam.
    • Department of Surgical Services, Naval Hospital Pensacola, Pensacola, FL 32412, USA.
    • Mil Med. 2024 Jul 3; 189 (7-8): e1813e1818e1813-e1818.

    AbstractDuring deployment, a 52-year-old male developed acute behavioral changes. Though initially considered to have PTSD and related agitation and confusional state, his evaluation was consistent with acute encephalopathy. Magnetic resonance imaging of the brain showed T2 hyperintensities, and CSF analysis was positive for anti-N-methyl-D-aspartate receptor antibody. A nuclear protein in testis carcinoma midline carcinoma was discovered in the lung. Immunotherapy and surgical resection led to steady improvement prior to adjuvant chemotherapy. Autoimmune encephalitis due to anti-N-methyl-D-aspartate receptor antibodies is increasingly being recognized as causal of acute behavioral change.© The Association of Military Surgeons of the United States 2024. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site–for further information please contact journals.permissions@oup.com.

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