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Annals of neurology · Jun 2005
Gene transfer of glutamic acid decarboxylase reduces neuropathic pain.
- Shuanglin Hao, Marina Mata, Darren Wolfe, Shaohua Huang, Joseph C Glorioso, and David J Fink.
- Department of Neurology, University of Michigan Health System and Ann Arbor VA Healthcare System, Ann Arbor, MI 48109-0316, USA.
- Ann. Neurol. 2005 Jun 1;57(6):914-8.
AbstractWe tested whether transfer of the gene coding for glutamic acid decarboxylase to dorsal root ganglion using a herpes simplex virus vector to achieve release of GABA in dorsal horn would attenuate nociception in this condition. Subcutaneous inoculation of a replication-defective herpes simplex virus vector expressing glutamic acid decarboxylase (vector QHGAD67) 7 days after selective L5 spinal nerve ligation reversed mechanical allodynia and thermal hyperalgesia; the antiallodynic effect lasted 6 weeks and was reestablished by reinoculation. QHGAD67 inoculation also suppressed induction of c-Fos and phosphorylated extracellular signal-regulated kinase 1 and 2 in the spinal cord.
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