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Case Reports
An Autopsy Case of Antineutrophil Cytoplasmic Antibody-Associated Vasculitis Induced by Propylthiouracil.
- Genki Fujii, Ryosuke Yoshihara, Toshiki Hyodo, Ikuhiro Ishida, Ryoko Onishi, Masayo Fujimoto, and Keiji Iida.
- Division of Diabetes and Endocrinology, Hyogo Prefectural Kakogawa Medical Center, Japan.
- Intern. Med. 2024 Dec 1; 63 (23): 319732023197-3202.
AbstractAntineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a complication caused by antithyroid drugs, particularly propylthiouracil (PTU). Most patients experience organ failure due to the affects of the treatment regimen. We herein report the case of an 89-year-old woman whose severe AAV induced by PTU resulted in various instances of organ failure that eventually led to death after 9 years of PTU therapy. During autopsy, we identified five types of organ failure. As AAV is a potentially fatal disease, the development of various vasculitis symptoms during PTU therapy should therefore be carefully monitored.
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