• Journal of critical care · Aug 2024

    Major determinants of primary non function from kidney donation after Maastricht II circulatory death: A single center experience.

    • Ana Gaspar, Madalena Gama, de JesusGustavo NobreGNIntensive Care Department, Unidade Local de Saúde Santa Maria EPE, Lisbon, Portugal; ECMO Referral Centre, Unidade Local de Saúde Santa Maria EPE, Lisbon, Portugal; Clínica Universitária de Medicina Intensiva, Faculdade de Medicina , Sara Querido, Juliana Damas, João Oliveira, Marta Neves, Alice Santana, and João Miguel Ribeiro.
    • Intensive Care Department, Unidade Local de Saúde Santa Maria EPE, Lisbon, Portugal; ECMO Referral Centre, Unidade Local de Saúde Santa Maria EPE, Lisbon, Portugal. Electronic address: ana.c.s.gaspar@chln.min-saude.pt.
    • J Crit Care. 2024 Aug 1; 82: 154811154811.

    PurposeOrgan shortage greatly limits treatment of patients with end-stage chronic kidney. Maastricht type 2 donation after circulatory death (DCD) has been shown to have similar results in long term outcomes in kidney transplantation, when compared with brain dead donation. Our main goal was to assess Maastricht type 2 DCD and evaluate factors that impact on early graft function.MethodsA retrospective study was conducted in an ECMO Referral Centre. All patients who received a kidney transplant from Maastricht type 2 DCD were included in study. Early graft function and short term outcomes were assessed.ResultsFrom October 2017 to December 2022, 47 renal grafts were collected from 24 uDCD donors. Median warm ischemia time was 106 min (94-115), cannulation time was 10 min (8; 20) and duration of extracorporeal reperfusion (ANOR) was 180 min (126-214). Regarding early graft function, 25% had immediate graft function, 63.6% had delayed graft function and 11.4% had primary non-function (PNF). There was a correlation between cannulation time (p = 0.006) and ANOR with PNF (p = 0.016).ConclusionsCannulation time and ANOR were the main factors that correlated with PNF. Better understanding of underlying mechanisms should be sought in future studies to reduce the incidence of PNF.Copyright © 2024 Elsevier Inc. All rights reserved.

      Pubmed     Copy Citation     Plaintext  

      Add institutional full text...

    Notes

     
    Knowledge, pearl, summary or comment to share?
    300 characters remaining
    help        
    You can also include formatting, links, images and footnotes in your notes
    • Simple formatting can be added to notes, such as *italics*, _underline_ or **bold**.
    • Superscript can be denoted by <sup>text</sup> and subscript <sub>text</sub>.
    • Numbered or bulleted lists can be created using either numbered lines 1. 2. 3., hyphens - or asterisks *.
    • Links can be included with: [my link to pubmed](http://pubmed.com)
    • Images can be included with: ![alt text](https://bestmedicaljournal.com/study_graph.jpg "Image Title Text")
    • For footnotes use [^1](This is a footnote.) inline.
    • Or use an inline reference [^1] to refer to a longer footnote elseweher in the document [^1]: This is a long footnote..

    hide…