• de SousaBruno MacedoBMInstitute for Occlusion and Orofacial Pain Faculty of Medicine, University of Coimbra, Coimbra, Portugal., Antonio López-Valverde, Francisco Caramelo, Maria Joao Rodrigues, and Nansi López-Valverde.
• Institute for Occlusion and Orofacial Pain Faculty of Medicine, University of Coimbra, Coimbra, Portugal.
• Med Clin (Barc). 2024 Jul 26; 163 (2): 747774-77.

Background And ObjectiveTemporomandibular disorders (TMDs) are a common pathology, associated with pain in the facial territory and with associated psychological disorders, such as anxiety and depression. The aim of this study was to evaluate the efficacy of antidepressants in the treatment of pain associated with TMD.Materials And MethodsSixty four patients suffering from chronic orofacial pain, randomly distributed in 3 groups: control group treated with night splint, group treated with 10mg/day of citalopram and group treated with 25mg/day of amitriptyline. Pain intensity was assessed, randomly, by a single blinded evaluator, according to the VAS at baseline and after one, three, six and nine weeks.ResultsAll groups showed a reduction of pain throughout the period of time evaluated, however, the group treated with amitriptyline showed the best pain reduction results 3.3±1.5, 1.5±1.4 and 0.9±1.3 at 3, 6 and 9 weeks, respectively.ConclusionsLow doses of amitriptyline appear to be a good therapeutic option in patients with TMDs suffering from chronic orofacial pain.Copyright © 2024 Elsevier España, S.L.U. All rights reserved.

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