• Medicina clinica · Jul 2024

    Observational Study

    Left ventricular concentric remodeling in COPD patients: A cross-sectional observational study.

    • Naiara Tais Leonardi, Camila da Silva Rocha Tomaz, Erika Zavaglia Kabbach, Alessandro Domingues Heubel, Nathany Souza Schafauser, Débora Mayumi de Oliveira Kawakami, Audrey Borghi-Silva, Goi RoscaniMelizaMDepartment of Medicine, Federal University of Sao Carlos (UFSCar), Rodovia Washington Luís, Km 235, Jardim Guanabara, 13565-905 São Carlos, São Paulo, Brazil., Viviane Castello-Simões, and Gonçalves MendesRenataRDepartment of Physical Therapy, Federal University of Sao Carlos, Rodovia Washington Luís, Km 235, Jardim Guanabara, 13565-905 São Carlos, São Paulo, Brazil. Electronic address: renatamendes@ufscar.br..
    • Department of Physical Therapy, Federal University of Sao Carlos, Rodovia Washington Luís, Km 235, Jardim Guanabara, 13565-905 São Carlos, São Paulo, Brazil.
    • Med Clin (Barc). 2024 Jul 12; 163 (1): 8138-13.

    ObjectiveTo investigate the association between left ventricular structure and disease severity in COPD patients.MethodsTwenty-eight COPD patients were stratified according to the disease severity, using the BODE index, into Lower (n=17) and Higher (n=11) groups, composed of patients with lower severity (BODE <5) and higher severity (BODE ≥5), respectively. Left ventricle (LV) was assessed by 2D-echocardiography. BODE index was calculated using body mass index (BMI); forced expiratory volume in the first second (FEV1, %); modified Medical Research Council (mMRC) and distance walked during 6-minute walk test (6MWD).ResultsPatients in the Higher group showed lower oxygen arterial saturation (p=0.02), FEV1 (p<0.01) and 6MWD (p=0.02) and higher value of relative posterior wall thickness (RWT) compared to Lower group (p=0.02). There were significant associations between LV end-systolic diameter (LVESD) and BODE index (r=-0.38, p=0.04), LV end-diastolic diameter (LVEDD) and FEV1 (r=0.44, p=0.02), LVEDD and BMI (r=0.45, p=0.02), LVESD and BMI (r=0.54, p=0.003) and interventricular septal thickness and 6MWD (r=-0.39, p=0.04).ConclusionsMore severe COPD patients, BODE score ≥5, may have higher RWT, featuring a possible higher concentric remodeling of LV in this group. Besides that, a greater disease severity may be related to LV chamber size reduction.Copyright © 2024 Elsevier España, S.L.U. All rights reserved.

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