• Eur. J. Intern. Med. · Aug 2024

    Observational Study

    Prognostic value of 18 FDG-PET at diagnosis and follow-up in giant cell arteritis: An observational restrospective study.

    • Anne-Claire Billet, Thomas Thibault, Éric Liozon, Hubert De Boysson, Laurent Perard, Olivier Espitia, Aurélie Daumas, Quentin Gomes De Pinho, Cécile-Audrey Durel, Arnaud Hot, Boris Bienvenu, Sébastien Humbert, Claude Bachmeyer, Sabine Mainbourg, Thomas Sené, Hervé Devilliers, Bastien Durand Bailloud, Hélène Greigert, Alexandre Cochet, Bernard Bonnotte, Jean-Louis Alberini, Maxime Samson, and French Study Group for Large Vessel Vasculitis (GEFA).
    • Department of Internal Medicine and Clinical Immunology, Referral Center for Rare Systemic Autoimmune and Autoinflammatory Diseases (MAIS), Dijon Bourgogne University Hospital, Dijon, France.
    • Eur. J. Intern. Med. 2024 Aug 1; 126: 697669-76.

    ObjectivesTo evaluate the ability of 18FDG PET/CT, at diagnosis of giant cell arteritis (GCA) and during follow-up, to predict occurrence of relapse in large-vessel GCA (LV-GCA).MethodsWe conducted a retrospective study using the French Study Group for Large-Vessel Vasculitis (GEFA) network. Data from patients with LV-GCA diagnosed by PET/CT and who had PET/CT in the following year were collected. For each PET/CT, PET vascular activity score (PETVAS) and total vascular score (TVS) were assessed, and their ability to predict the occurrence of subsequent relapse was assessed.ResultsA total of 65 LV-GCA patients were included, of whom 55 had undergone a follow-up PET/CT 3 to 12 months after the diagnosis of GCA. Patients for whom the second PET/CT (PET2) was performed during active GCA were excluded. PETVAS and TVS decreased between PET1 and PET2 in all patients (p < 0.001). There was no correlation between vascular activity scores in PET2 and time to prednisone taper. For relapse prediction, at PET1, the AUC of the TVS and PETVAS were respectively 51.9 and 41.9 at 6 months, 55.3 and 49.7 at 1 year, 55 and 55.7 at 2 years. For PET2, the AUC were respectively 46.1 and 46.7 at 6 months, 52.1 and 48.9 at 1 year, 58.4 and 52.3 at 2 years.ConclusionPET vascular activity scores at diagnosis and at follow-up PET/CT performed outside a period of GCA activity do not display high performance to predict the occurrence of subsequent relapse in LV-GCA patients.Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved.

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