• Suprabhat Giri, Sushrut Ingawale, Sidharth Harindanath, Mohit Jain, Pranav Garg, Harish Darak, Sanjay Kumar, Aditya Kale, and Akash Shukla.
• Department of Gastroenterology, Seth GS Medical College & KEM Hospital, Mumbai, Maharashtra, India.
• Indian J Med Res. 2024 Feb 1; 159 (2): 213222213-222.

Background ObjectivesAlcohol is one of most common aetiologies of cirrhosis and decompensated cirrhosis is linked to higher morbidity and death rates. This study looked at the outcomes and mortality associated risk variables of individuals with alcoholic cirrhosis who had hospitalization with their first episode of decompensation.MethodsIndividuals with alcoholic cirrhosis who were hospitalized with the first episode of decompensation [acute decompensation (AD) or acute-on-chronic liver failure (ACLF)] were included in the study and were prospectively followed up until death or 90 days, whichever was earlier.ResultsOf the 227 study participants analyzed, 167 (73.56%) and 60 (26.43%) participants presented as AD and ACLF, respectively. In the ACLF group, the mortality rate at 90 days was higher than in the AD group (48.3 vs 32.3%, P=0.02). In the AD group, participants who initially presented with ascites as opposed to variceal haemorrhage had a greater mortality rate at 90 days (36.4 vs 17.1%, P=0.041). The chronic liver failure-consortium AD score and the lactate-free Asian Pacific Association for the study of the Liver-ACLF research consortium score best-predicted mortality in individuals with AD and ACLF.Interpretation ConclusionsThere is significant heterogeneity in the type of decompensation in individuals with alcoholic cirrhosis. We observed significantly high mortality rate among alcoholic participants hospitalized with initial decompensation; deaths occurring in more than one-third of study participants within 90 days.Copyright © 2024 Copyright: © 2024 Indian Journal of Medical Research.

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