• Christiaan van Nispen, Brit Long, and Alex Koyfman.
• Department of Emergency Medicine, Brooke Army Medical Center, Fort Sam Houston, TX, United States of America. Electronic address: cvannispenmd@gmail.com.
• Am J Emerg Med. 2024 Jul 1; 81: 162216-22.

IntroductionStevens Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are serious conditions that carry a high rate of morbidity and mortality.ObjectiveThis review highlights the pearls and pitfalls of SJS/TEN, including presentation, diagnosis, and management in the emergency department (ED) based on current evidence.DiscussionSJS/TEN is a rare, delayed hypersensitivity reaction resulting in de-epithelialization of the skin and mucous membranes. The majority of cases are associated with medication or infection. Clinicians should consider SJS/TEN in any patient presenting with a blistering mucocutaneous eruption. Evaluation of the skin, mucosal, pulmonary, renal, genital, and ocular systems are essential in the diagnosis of SJS/TEN, as well as in the identification of complications (e.g., sepsis). Laboratory and radiological testing cannot confirm the diagnosis in the ED setting, but they may assist in the identification of complications. ED management includes stabilization of airway and breathing, fluid resuscitation, and treatment of any superimposed infections with broad-spectrum antibiotic therapy. All patients with suspected SJS/TEN should be transferred and admitted to a center with burn surgery, critical care, dermatology, and broad specialist availability.ConclusionsAn understanding of SJS/TEN can assist emergency clinicians in diagnosing and managing this potentially deadly disease.Copyright © 2024. Published by Elsevier Inc.

13 keywords...

hide…