• Lili Zhang, Lanying He, Jing Huang, Sixie Ren, and Jian Wang.
• Department of Neurology, The Second People's Hospital of Chengdu, Chengdu, China.
• Medicine (Baltimore). 2024 Apr 12; 103 (15): e37719e37719.

RationaleTransverse spinal cord infarction (SCI) is rare but highly disabling. Aortic thrombosis was described as one of the most common etiologies. Thromboembolic complications associated with intravenous immunoglobulin (IVIG) have been reported.Patient ConcernsA previously well, 64-year-old man who was given the treatment of IVIG (0.4 g/kg/d for 5 days) for exfoliative dermatitis 2 weeks before, progressively developed flaccid paraplegia of lower extremities, loss of all sensations below T3 level and urinary incontinence within 50 minutes.DiagnosesA diagnosis of SCI and pulmonary embolism was made. IVIG was considered the possible cause.InterventionsAnticoagulation treatment and continuous rehabilitation were administered.OutcomesThe neurologic deficiency of the patient was partially improved at the 3-year follow-up.LessonsThe rapid development of severe deficits within 4 hours mostly contributes to the diagnosis of SCI. Heightened awareness of possible thrombotic events is encouraged for a month-long period following IVIG therapy.Copyright © 2024 the Author(s). Published by Wolters Kluwer Health, Inc.

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