• Xiaoyun Wang, Ru Ma, Jizhou Ma, Na Tang, Rui Li, and Xiaojin Ma.
• Department of Gastroenterology, The First People's Hospital of Shizuishan, Affiliated to Ningxia Medical University, Shizuishan, China.
• Medicine (Baltimore). 2024 Apr 19; 103 (16): e37877e37877.

RationaleInflammatory fibroid polyp (IFP), also known as Vanek tumor, is a rare, benign gastrointestinal lesion characterized by its inflammatory and fibroid histological features. IFP is often discovered incidentally during endoscopic examinations. It is exceedingly rare for an IFP to prolapse into the duodenum and results in incomplete obstruction of the pylorus.Patient ConcernsA 64-year-old male patient was admitted to the hospital with recurrent episodes of melena over a 6-month period, along with complaints of dizziness and fatigue in the past 10 days.DiagnosesGastroscopy showed a giant polypoid mass on the posterior wall of the gastric antrum, prolapsing into the duodenum. Abdominal computer tomography (CT) confirmed the tumor protruding into the duodenum. Pathologic examination of the resected specimen confirmed the IFP diagnosis.InterventionsThe giant tumor was completely and successfully excised using endoscopic submucosal dissection (ESD). After the surgery, the patient underwent acid suppression and fluid replenishment therapy.OutcomesThe patient responded well to ESD and was discharged in stable condition. As of the submission of the case report, there has been no recurrence of the tumor after a 5-month follow-up, and the patient is still under follow-up.LessonsWhile IFPs have traditionally been managed surgically, ESD demonstrates promising treatment outcomes, avoiding the need for surgical distal gastrectomy, and emerges as a safe and effective treatment option.Copyright © 2024 the Author(s). Published by Wolters Kluwer Health, Inc.

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