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- M Essand and A S I Loskog.
- Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden. magnus.essand@igp.uu.se
- J. Intern. Med. 2013 Feb 1; 273 (2): 166181166-81.
AbstractT-cell immunotherapy is a promising approach to treat disseminated cancer. However, it has been limited by the ability to isolate and expand T cells restricted to tumour-associated antigens. Using ex vivo gene transfer, T cells from patients can be genetically engineered to express a novel T cell receptor or chimeric antigen receptor to specifically recognize a tumour-associated antigen and thereby selectively kill tumour cells. Indeed, genetically engineered T cells have recently been successfully used for cancer treatment in a small number of patients. Here we review the recent progress in the field, and summarize the challenges that lie ahead and the strategies being used to overcome them.© 2012 The Association for the Publication of the Journal of Internal Medicine.
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