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- Harsha Shanthanna and Girish P Joshi.
- Department of Anesthesia, McMaster University, Hamilton, ON, Canada. Electronic address: shanthh@mcmaster.ca.
- Br J Anaesth. 2024 May 1; 132 (5): 102710321027-1032.
AbstractThe conduct and reporting of studies with a noninferiority hypothesis is challenging because of the complexity involved in their design and interpretation. However, studies with a noninferiority design have increased in popularity. A recently published trial reported on the noninferiority of lidocaine infusion to epidural analgesia in major abdominal surgeries. Apart from needing a critical appraisal, this draws attention to improve our understanding of noninferiority study framework and its unique features. Given the increasing focus on using various analgesic adjuncts and multiple approaches to fascial plane blocks to avoid more definitive and standard approaches, it is imperative that particular attention is paid to appropriate execution and reporting of noninferiority studies.Copyright © 2024 British Journal of Anaesthesia. Published by Elsevier Ltd. All rights reserved.
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