• Clin Med (Lond) · Jun 2018

    Case Reports

    Lesson of the month 2: An unusual adverse reaction associated with pramipexole.

    • Yasmina Tashkent and Vinod Aiyappan.
    • Flinders Medical Centre, Adelaide, Australia Yasmina.Tashkent@sa.gov.au.
    • Clin Med (Lond). 2018 Jun 1; 18 (3): 259260259-260.

    AbstractDopamine agonists such as pramipexole are commonly used in the treatment of restless legs syndrome (RLS) as well as Parkinson's disease. Pramipexole's common side effects are well documented; however, adverse skin reactions are less well known. In this case, a 45-year-old male farmer presented with excessive daytime tiredness and reported a history suggestive of RLS. He was initiated on pramipexole but developed a maculopapular erythematous rash in sun-exposed areas 8 days after its commencement. The skin rash resolved following pramipexole's cessation and it is thought the patient experienced a drug-induced photosensitivity reaction to pramipexole. This case highlights the potential for photosensitivity reactions to pramipexole, which is especially significant in countries like Australia where UV solar radiation is especially high.© Royal College of Physicians 2018. All rights reserved.

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