• Clin Med (Lond) · Feb 2016

    Severe adverse drug reactions.

    • Ying Xin Teo and Sarah Anne Walsh.
    • King's College Hospital, London, UK yteo20@gmail.com.
    • Clin Med (Lond). 2016 Feb 1; 16 (1): 798379-83.

    AbstractSevere cutaneous adverse reactions (SCARs) can present in a multitude of ways including Stevens-Johnson syndrome, toxic epidermal necrolysis, drug reaction with eosinophilia and systemic symptoms, and acute generalised exanthematous pustulosis. While the prognosis and therapy for these conditions may vary, it is crucial that the culprit drug is identified and withheld early as this can influence patient outcome. Mainstay of management is by supportive therapy. In all SCARs, long-term sequelae which may not be apparent initially can be debilitating and cause lasting impact on the quality of life of survivors.© Royal College of Physicians 2016. All rights reserved.

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