• Clin Med (Lond) · Oct 2016

    European drug market entries 2015 with new mechanisms of action.

    • Titus W P van den Heuvel, Adam F Cohen, and Robert Rissmann.
    • Leiden University Medical Centre, Leiden, the Netherlands.
    • Clin Med (Lond). 2016 Oct 1; 16 (5): 475480475-480.

    AbstractIn this article, we consider the new drugs approved for the European market in 2015. We present a summary of the new mechanisms of action introduced and highlight three new mechanisms of action with a potentially high future impact: PCSK9 inhibition (alirocumab (Praluent®) and evolocumab (Repatha®)) for hypercholesterolaemia, neprilysin inhibition (sacubitril in combination with valsartan (Entresto®)) for heart failure, and interleukin-5 inhibition (mepolizumab (Nucala®)) for asthma.© Royal College of Physicians 2016. All rights reserved.

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