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The Journal of pediatrics · Aug 2014
Clinical and neuroimaging findings in neonatal herpes simplex virus infection.
- Monika Bajaj, Swati Mody, and Girija Natarajan.
- Carman and Ann Department of Pediatrics, Wayne State University, Detroit, MI. Electronic address: mbajaj@dmc.org.
- J. Pediatr. 2014 Aug 1;165(2):404-407.e1.
AbstractIn a retrospective review of infants with neonatal herpes simplex virus disease (n=29), we found bilateral multilobar (n=8), pontine (n=3), thalamic (n=6), and internal capsule and corticospinal tract (n=5) involvement on magnetic resonance imaging (MRI). Diffusion-weighted imaging (n=6) performed early revealed additional involvement than detected by conventional MRI. Neurodevelopmental sequelae were correlated with MRI abnormalities. Our findings demonstrate that MRI, including diffusion-weighted imaging, is a valuable prognostic adjunct in neonatal herpes simplex virus disease.Copyright © 2014 Elsevier Inc. All rights reserved.
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