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- R Alexander Speight and John C Mansfield.
- Department of Gastroenterology, Newcastle upon Tyne Hospitals NHS Foundation Trust, UK.
- Clin Med. 2013 Aug 1; 13 (4): 378382378-82.
AbstractThe pathogenesis of inflammatory bowel disease (IBD) remains incompletely understood, but is thought to be a consequence of immune dysregulation, impaired mucosal integrity, enteric bacterial dysbiosis and genetic susceptibility factors. Recent drug advances in the treatment of IBD have clarified the role of existing medication, including 5-amino-salicylic acids (5-ASAs) and has seen a burgeoning use of treatment with biologicals. With recent advances in our understanding of these debilitating diseases, it is hoped that novel therapeutic targets can be identified.
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