• Jack Stewart Davey, Randi Rotne, and Glenn Edwards.
• Animal Referral Hospital Canberra, 364 Fairbairn Ave, Pialligo, ACT, 2609, Australia; School of Animal, Environmental and Veterinary Sciences, Charles Sturt University, Wagga, NSW 2678, Australia. Electronic address: j.davey@arhvets.com.
• Injury. 2024 Jun 1; 55 (6): 111543111543.

BackgroundThe early identification of delayed bone healing or a non-union is vital for prompt treatment and superior patient outcomes. Current techniques rely heavily on operator skill for interpretation and hence their reliability and repeatability may be inconsistent. This study assessed the application of computed tomography (CT) derived densiometric measurements as a quantitative tool for the assessment of bone healing.MethodsThis prospective, longitudinal, method comparison study was performed using a recognised sheep tibial ostectomy model. Secondary bone healing was assessed at 2, 4, 6, and 8 weeks after the ostectomy was performed. CT densiometric measures of bone healing (Hounsfield units) were taken of the cis, trans, cranial and caudal cortices relative to the bone plate, with histological measurements (percentage of ossification) sourced from the same areas. Cis cortical densiometric data points were excluded from analysis due to significant beam hardening artefact from the bone plate (P < 0.001). A univariable linear regression was performed on the remaining data using averaged radiodensity (independent variable) and histomorphometric (dependent variable) measurements.ResultsThe two measurements were significantly correlated (R2 = 0.623, P = 0.020) with a clear positive trend identified.ConclusionThis study suggests that radiodensity measurements may be a useful diagnostic and management tool for the monitoring of indirect bone healing.Copyright © 2024 Elsevier Ltd. All rights reserved.

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