• Okan Sancer, Uğur Şahin, Emel Sesli Çetin, Muhammet Yusuf Tepebaşi, Yasemin Cezaroğlu, Göksel Bilir, Sibel Yünlü, and Ahmet Koca.
• Suleyman Demirel University, Faculty of Medicine, Department of Medical Biology - Isparta, Turkey.
• Rev Assoc Med Bras (1992). 2024 Jan 1; 70 (3): e20230683e20230683.

ObjectiveIn this study, we aimed to determine the phenolic compounds, the antibacterial activity of extract from Laurus nobilis leaves, and its possible effect on transforming growth factor-β1 expression level in peripheral blood mononuclear cells.MethodsThe phenolic components of Laurus nobilis were identified by the high-performance liquid chromatography method. The antibacterial activity of this extract was determined by disk diffusion and broth microdilution methods. The transforming growth factor-β1 expression was analyzed using the RT-qPCR method.ResultsEpicatechin was found in the highest amount and o-coumaric acid in the lowest amount. The half-maximal inhibitory concentration (IC50) was determined to be 55.17 μg/mL. The zones of inhibition and minimum inhibitory concentration for Staphylococcus aureus, Enterococcus faecalis, and Klebsiella pneumoniae were 15, 14, and 8 mm and 125, 250, and 1000 μg/mL, respectively. The change in transforming growth factor-β1 expression levels was found to be statistically significant compared with the control groups (p<0.0001).ConclusionLaurus nobilis extract was found to be effective against bacteria and altered the expression level of transforming growth factor-β1 in peripheral blood mononuclear cells.

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