• Masui · Jun 2011

    Case Reports

    [Use of sugammadex in a patient with limb girdle muscular dystrophy].

    • Kouichi Mogi, Satomi Shiba, Yoshihiro Hirabayashi, and Norimasa Seo.
    • Department of Anesthesiology and Intensive Care Medicine, Jichi Medical University, Shimotsuke 329-0498.
    • Masui. 2011 Jun 1;60(6):710-2.

    AbstractLimb girdle muscular dystrophy, a chronic progressive muscular atrophic disease, leads to high sensitivity to depolarizing and non-depolarizing neuromuscular blocking agents. We report the successful use of the sugammadex in a patient with limb girdle muscular dystrophy (dysferlinopathy, Miyoshi distal myopathy) to reverse rocuronium-induced neuromuscular block. After neuromuscular recovery to a train-of-four ratio = 43%, we administered 3.2 mg x kg(-1) of sugammadex (200 mg) intravenously, reversing neuromuscular blockade to a train-of-four ratio = 95% within 3 min. Sugammadex can be used to reverse rocuronium-induced neuromuscular blockade in patients with limb girdle muscular dystrophy.

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