• Yinluo Li, Xingzhen Long, Fengrong Luo, Jiarui Zhang, Shaoqin Sun, Pengqiang Du, Hongtao Yang, Qi Chen, Changcheng Sheng, and Xue Bai.
• Department of Pharmacy, Guizhou Provincial People's Hospital.
• Clin J Pain. 2024 Jul 1; 40 (7): 440446440-446.

ObjectiveThis study aimed to systematically evaluate the clinical efficacy of gabapentin and pregabalin in the treatment of acute herpes zoster (HZ) neuralgia, including pain control and the occurrence of adverse effects.MethodsA systematic computerized search was conducted in October 2023 in PubMed, Embase, Web of Science, Cochrane Library, VIP, CNKI, and Wanfang databases. Data from randomized controlled trials (RCTs) comparing gabapentin analogs for the treatment of acute HZ neuralgia were searched. Endpoints were visual analog scores (Visual Analog Scale) and adverse effects at 1, 2, and 4 weeks. Data from studies that met the inclusion criteria were extracted for meta-analysis and sensitivity analysis using Revman 5.4 and Stata16.ResultsThe study included 292 patients from 6 RCTs. Of these, 118 were in the gabapentin-treated group, 37 were in the pregabalin-treated group, and 137 were in the placebo-controlled group. The gabapentin group showed superior pain reduction compared with the placebo group ( P < 0.05), but adverse events were more frequent.ConclusionGabapentin can effectively reduce acute HZ neuralgia in patients. Pregabalin requires additional RCTs to supplement the analysis.Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.

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