• Cássia Lima de Oliveira Gracini, Gustavo Giacomelli Nascimento, Maria Tereza Campos Vidigal, Murilo Navarro de Oliveira, Álex Moreira Herval, Cauane Blumenberg, Walbert A Vieira, Rafael Rodrigues Lima, and Luiz Renato Paranhos.
• MSc. Nurse, Master's student, Postgraduate Program in Management and Public Health, Universidade Estadual de Campinas (UNICAMP), Piracicaba (SP), Brazil.
• Sao Paulo Med J. 2024 Jan 1; 142 (4): e2022641e2022641.

BackgroundAdolescence is characterized by complex and dynamic changes, often involving experimentation, including the use of psychotropic substances. Although it is well-established that recreational psychotropic drugs are associated with suicide ideation in adults, evidence of this association in adolescents remains limited.ObjectiveTo investigate the relationship between suicide ideation and psychotropic recreational drug use among adolescents.Design And SettingSystematic review with meta-analysis developed at Universidade Federal de Uberlândia (UFU) and Universidade Estadual de Campinas (UNICAMP), Brazil.MethodsA search across eight electronic databases for observational studies, without language or publication year restrictions, was conducted. The Joanna Briggs Institute tool was used to assess the risk of bias. Random-effects meta-analyses and odds ratios were used to measure the effects.ResultsThe search yielded 19,732 studies, of which 78 were included in the qualitative synthesis and 32 in the meta-analysis. The findings indicated that suicidal ideation was 1.96 times more likely (95% confidence interval, CI = 1.47; 2.61) for adolescents who used some drug recurrently and 3.32 times more likely (95%CI = 1.86; 5.93) among those who abused drugs. Additionally, adolescents who used cannabis were 1.57 times more likely (95%CI = 1.34; 1.84) to experience suicide ideation compared with non-users, while cocaine users had 2.57 times higher odds (95%CI = 1.47; 4.50).ConclusionsPsychotropic recreational drug use is associated with suicidal ideation among adolescents regardless of current or previous use, abuse, or type of substance used.Systematic Review RegistrationRegistered in the PROSPERO database under the identification number CRD42021232360. https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42021232360.

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