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Yonsei medical journal · Feb 2008
Case ReportsRituximab-CHOP induced interstitial pneumonitis in patients with disseminated extranodal marginal zone B cell lymphoma.
- Kwang Min Kim, Ho-Cheol Kim, Kyung-Nyeo Jeon, Hoon-Gu Kim, Jung Hun Kang, Jong Ryeal Hahm, and Gyeong-Won Lee.
- Department of Internal Medicine, College of Medicine, Gyeongsang National University, Jinju 660-702, Korea.
- Yonsei Med. J. 2008 Feb 29; 49 (1): 155158155-8.
AbstractA 69-year-old male was diagnosed in February 2004 with stage IV extranodal marginal zone B cell lymphoma involving the mediastinal nodes, lung parenchyma and bone marrow with high LDH. Shortness of breath developed following the 5th course of Rituximab-CHOP chemotherapy (cyclophosphamide, Vincristine, Doxorubicin, Prednisolone). Bronchoscopy guided transbronchial lung biopsy revealed interstitial thickening and type II pneumocyte activation, compatible with interstitial pneumonitis. After treatment with prednisolone a complete resolution of the dyspnea was observed. The patient was well on routine follow-up at the outpatient clinic, with no progression of lymphoma or interstitial pneumonitis.
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