• Annals of neurology · Oct 1993

    Cerebrospinal fluid inhibits Alzheimer beta-amyloid fibril formation in vitro.

    • T Wisniewski, E Castano, J Ghiso, and B Frangione.
    • Department of Pathology, New York University Medical Center, NY 10016.
    • Ann. Neurol. 1993 Oct 1;34(4):631-3.

    AbstractAlzheimer's disease is characterized by the deposition of beta-protein (A beta) as amyloid. Recently, it was found that A beta is a normal component of serum and cerebrospinal fluid. Synthetic peptides homologous to A beta form amyloid-like fibrils spontaneously in water or physiological solutions. Using a peptide homologous to A beta 1-40, we find that fibril formation is inhibited by the presence of cerebrospinal fluid.

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