• Ann. N. Y. Acad. Sci. · Dec 2011

    Comparative Study

    Novel, nonreflex tests detect analgesic action in rodents at clinically relevant concentrations.

    • Nick Andrews, Sinead Harper, Yasmin Issop, and Andrew S C Rice.
    • Pain and Sensory Disorders Research Unit, Pfizer Laboratories, Sandwich, United Kingdom. naa170767@yahoo.co.uk
    • Ann. N. Y. Acad. Sci. 2011 Dec 1;1245:11-3.

    AbstractWe propose that predictive validity of tests for analgesia may be improved by looking to reinstate specific, innate behaviors suppressed by pain, e.g., burrowing, because effective plasma concentrations in the rat are closer to effective clinical plasma concentrations than those generally used in rodent reflex withdrawal assays.© 2011 New York Academy of Sciences.

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