• Aline Cristina Piratello, Ivana Moraes-Silva, Janaina Paulini, Pamella Ramona Souza, Raquel Sirvente, Vera Salemi, Karin Flues, Edson Dias Moreira, Cristiano Mostarda, Tatiana Cunha, Dulce Elena Casarini, and Maria Claudia Irigoyen.
• Heart Institute, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil. hipirigoyen@incor.usp.br
• Clinics (Sao Paulo). 2010 Jan 1; 65 (12): 134513501345-50.

ObjectiveThe aim of this study was to evaluate the role of angiotensin I, II and 1-7 on left ventricular hypertrophy of Wistar and spontaneously hypertensive rats submitted to sinoaortic denervation.MethodsTen weeks after sinoaortic denervation, hemodynamic and morphofunctional parameters were analyzed, and the left ventricle was dissected for biochemical analyses.ResultsHypertensive groups (controls and denervated) showed an increase on mean blood pressure compared with normotensive ones (controls and denervated). Blood pressure variability was higher in denervated groups than in their respective controls. Left ventricular mass and collagen content were increased in the normotensive denervated and in both spontaneously hypertensive groups compared with Wistar controls. Both hypertensive groups presented a higher concentration of angiotensin II than Wistar controls, whereas angiotensin 1-7 concentration was decreased in the hypertensive denervated group in relation to the Wistar groups. There was no difference in angiotensin I concentration among groups.ConclusionOur results suggest that not only blood pressure variability and reduced baroreflex sensitivity but also elevated levels of angiotensin II and a reduced concentration of angiotensin 1-7 may contribute to the development of left ventricular hypertrophy. These data indicate that baroreflex dysfunction associated with changes in the renin angiotensin system may be predictive factors of left ventricular hypertrophy and cardiac failure.

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