• Hazza A Alhobeira, Anamika Sharma, Ananya Sharma, Mahvish Khan, Mohtashim Lohani, Saif Khan, Eslam K Fahmy, Safya E Esmaeel, and Anshoo Agarwal.
• Department of Restorative Dentistry, College of Dentistry, University of Ha'il, Ha'il 55473, Saudi Arabia.
• Ir J Med Sci. 2024 Aug 1; 193 (4): 194919551949-1955.

BackgroundCytokines, including interleukin-12 (IL-12), are proteins that regulate cell survival, proliferation, differentiation, and function. IL-12 is a heterodimeric proinflammatory cytokine. It possesses tumoricidal properties and promotes M1 macrophage polarization and IFN-γ production by T helper (Th1) cells, which in turn stimulates the antitumor cytotoxic cluster of eight positive (CD8+) and natural killer cells, therefore activating an effector immune response against tumor cells.Materials And MethodsHerein, the IL-2 levels of 60 patients with generalized chronic periodontitis (GCP) were assessed. Plaque index, gingival index, pocket probing depth, bleeding on probing percentage (BOP %), and clinical attachment loss were the clinical indicators reported.ResultsPatients with GCP in the pretreatment group had substantially lower mean IL-12 levels than those in the post-treatment group. Short-term, nonsurgical treatment (NST) considerably improved periodontal indices and increased IL-12 levels, thereby reducing oral cancer risk.ConclusionNST is a cost-effective and accessible cancer prevention procedure for general dentists.© 2024. The Author(s), under exclusive licence to Royal Academy of Medicine in Ireland.

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