• Oral Surg Oral Med Oral Pathol Oral Radiol Endod · May 2008

    Assessment of the biocompatibility of Epiphany root canal sealer in rat subcutaneous tissues.

    • Mônica Maria Denadae de Campos-Pinto, Danilo Alessandro de Oliveira, Marco Aurélio Versiani, Yara Teresinha Correa Silva-Sousa, Manoel Damião de Sousa-Neto, and Danyel Elias da Cruz Perez.
    • School of Dentistry, University of Ribeirao Preto, Ribeirao Preto, Brazil.
    • Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2008 May 1;105(5):e77-81.

    ObjectiveThe aim of this study was to evaluate the biocompatibility of the root canal sealer Epiphany in rat subcutaneous tissues.Study DesignPolyethylene tubes were filled with the sealer (I: Epiphany; II: photoactivated Epiphany; III: Epiphany associated with self-etch primer; IV: photoactivated Epiphany associated with primer; and V: control group) and later implanted into 4 different regions of the dorsum of 15 adult male rats (Rattus novergicus, Albinus Wistar). After 7, 21, and 42 days, 5 animals were killed, obtaining 4 samples per group, in addition to the control group, at each analyzed time.ResultsIn all periods, Epiphany induced a mild inflammatory reaction. However, in group II, in which the primer was not used, extensive necrosis and a moderate to intense inflammatory reaction were observed, mainly after 7 and 21 days.ConclusionEpiphany sealer appears biocompatible when tested on rat subcutaneous tissues.

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