• J Headache Pain · Oct 2010

    Review

    Verisimilitude (or "truthlikeness") as an alternative to pro and cons: migraine and cluster headache mechanisms.

    • Peer Carsten Tfelt-Hansen.
    • Department of Neurology, Danish Headache Centre, Glostrup Hospital, University of Copenhagen, Glostrup, Denmark. ptha@glo.regionh.dk
    • J Headache Pain. 2010 Oct 1; 11 (5): 379389379-89.

    AbstractCalculating verisimilitude (or "truthlikeness") ad modum Popper is a quantitative alternative to the usual pros and cons in migraine and cluster headache mechanisms. The following items were evaluated: dilation of large cranial arteries during migraine; CGRP increase during migraine; migraine as a brain disorder; aura and migraine headache; brain stem activation during migraine; rCBF in migraine without aura; NO and pathophysiology of migraine; neurogenic inflammation and migraine; aura in cluster headache; and hypothalamic activation in cluster headache. It is concluded that verisimilitude calculations can be helpful when judging pathophysiological problems in migraine and cluster headache.

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