• Clin Med (Lond) · May 2024

    Case Reports

    Statin-Induced, Immune-Mediated Necrotizing Myopathy Triggered by Malignancy Successfully Treated with Immunosuppression.

    • Ahmed Abouelazm, Kirollos Philops, Amr Amine, and Yahia Golam.
    • Portsmouth University Hospital, UK. Electronic address: Ahmed.Abouelazm@porthosp.nhs.uk.
    • Clin Med (Lond). 2024 May 1; 24 (3): 100217100217.

    AbstractStatin-induced immune-mediated necrotising myopathy (IMNM) is an inflammatory myopathy that can present as proximal muscle weakness and, in some cases, as dysphagia and respiratory distress. In this report, we present a case of statin-induced IMNM in a 78-year-old male. The patient had significantly high levels of creatinine kinase and myoglobinuria and experienced gradual weakness in the proximal muscles for 1 month after initiating a 20 mg dose of Atorvastatin 10 months before admission. Rapid clinical improvement was observed with the use of high-dose glucocorticoids in conjunction with methotrexate.Crown Copyright © 2024. Published by Elsevier Ltd. All rights reserved.

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