• Eur J Trauma Emerg Surg · Aug 2024

    Randomized Controlled Trial Comparative Study

    Comparison of analgesic efficacy of ibuprofen and dexketoprofen in pain management of long bone fractures: a prospective, randomized, double-blind study.

    • Safa Dönmez, Alp Sener, Nurullah Ishak Isık, İlker Akbas, Kadir Yenal, and Bekir Kaya.
    • Ministry of Health Ankara Bilkent City Hospital, Emergency Medicine, Ankara, Turkey. drsafa0131@gmail.com.
    • Eur J Trauma Emerg Surg. 2024 Aug 1; 50 (4): 179117981791-1798.

    IntroductionLong bone fractures (LBF) often cause severe pain, impacting patients' quality of life. This prospective, randomized, double-blind study aimed to compare the analgesic efficacy of dexketoprofen (Dex) and ibuprofen (Ibu) in LBF patients in the emergency department.MethodsConducted between August 10, 2023, and January 17, 2024, the study included 100 eligible patients randomized into Dex and Ibu groups. Visual analog scale (VAS) scores were measured at baseline and at 30, 60, and 120 min. DeltaVAS (ΔVAS) values and ΔVAS percentages (ΔVAS%) were calculated. Primary endpoints were ΔVAS scores (ΔVAS 30-60-120) and ΔVAS% for comparative analysis.ResultsStatistical analysis showed no significant difference in ΔVAS30 (p = 0.359). However, ΔVAS60 exhibited a significant difference (p = 0.027), as did ΔVAS120 (p = < 0.001). ΔVAS%30 showed no significance (p = 0.224), but ΔVAS%60 and ΔVAS%120 were clinically and statistically significant (p = 0.017 and p = < 0.001, respectively).ConclusionIbuprofen 800 mg demonstrated superior analgesic efficacy at 60 and 120 min compared to Dex in long bone fractures. These findings suggest ibuprofen's potential as an effective pain management option in emergency departments.© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany.

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