• Internal medicine · May 2024

    Successful Management of Total Plasma Exchange for Hemolytic Cold Agglutinin Disease.

    • Takahiro Shima, Hiromi Iwasaki, Tomoko Henzan, Koji Kato, and Koichi Akashi.
    • Department of Medicine and Biosystemic Science, Kyushu University Hospital, Japan.
    • Intern. Med. 2024 May 9.

    AbstractTherapeutic plasma exchange (TPE) is a strategy for treating cold agglutinin disease (CAD) in order to manage hemolytic complications. However, there are no reports of hemolysis during TPE. A 41-year-old man with secondary CAD was unable to undergo initial TPE because of red blood cell agglutination and hemolysis in his extracorporeal circulation. To avoid low temperatures, the patient and extracorporeal circulation were kept warm by covering and heating them, and finally, he was able to successfully receive TPE three times. Although our approach still has room for improvement, our management protocol appears to be an effective treatment modality for such cases.

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