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- Hirotoshi Kawashima, Aiko Saku, Mai Konishi, Yuichiro Hayashi, Akira Watanabe, and Koichi Hirose.
- Department of Rheumatology, School of Medicine, International University of Health and Welfare, Japan.
- Intern. Med. 2024 May 9.
AbstractHistoplasmosis, a fungal infection caused by Histoplasma capsulatum, is endemic in many parts of the world. However, this is not common in Japan. We herein present a unique case of military histoplasmosis in a 45-year-old female with mixed connective tissue disease (MCTD) who was receiving immunosuppressive therapy. The histological findings coupled with molecular confirmation led to final a diagnosis. This case emphasizes the diagnostic challenges associated with histoplasmosis in immunocompromised patients and underscores the importance of considering it in the differential diagnosis of any atypical presentation in rheumatic patients.
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