• J. Investig. Med. · Dec 2024

    Review

    Advances in research on renal injury in paroxysmal nocturnal.

    • Liyan Li and Rong Fu.
    • Tianjin Key Laboratory of Bone Marrow Failure and Malignant Hemopoietic Clone Control, Tianjin, P.R. China.
    • J. Investig. Med. 2024 Dec 1; 72 (8): 828833828-833.

    AbstractParoxysmal nocturnal hemoglobinuria (PNH) is an acquired clonal hematopoietic stem cell disease. Clinical manifestations include intravascular hemolysis, renal dysfunction, fatigue, jaundice, pulmonary hypertension, and so on. Renal injury, as a clinical feature of PNH, is difficult to diagnose and is one of the causes of death in patients with PNH. This article reviews the progress in research on PNH combined with renal injury to improve clinicians' understanding of renal injury in PNH patients, define and judge staging in a timely and accurate manner, enable patients to receive timely and appropriate treatment and reduce mortality.

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