Surgical removal of extended-release buprenorphine depot due

Am J Emerg Med · Jul 2024

Case Reports

Surgical removal of extended-release buprenorphine depot due to adverse reactions.

Extended-release formulations of buprenorphine offer less frequent dosing, provide consistent medication delivery, and improve adherence for treatment of opioid use disorder (OUD). Although buprenorphine is a partial agonist with seemingly less precipitated withdrawal and easier initiation than full opioid agonists used for OUD, its use is not benign and understanding of the different extended-release formulations is necessary. We report a case of a patient that received a long-acting buprenorphine formulation (Sublocade®) administered subcutaneously that presented to the emergency department with tachycardia, hyperglycemia, elevated anion gap, and sustained nausea and vomiting refractory to pharmacotherapy requiring surgical removal of the buprenorphine depot for resolution of nausea and vomiting symptoms.

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- Andrew Burton, Darlene J DeBona, Michele Handzel, Sarah Kelly-Pisciotti, Min Qiao, Dana Rojek, and Nicole M Acquisto.
- University of Rochester Medical Center - Thompson Health, 350 Parrish Street, Canandaigua, NY 14424, United States of America. Electronic address: aburton91312@rx.lecom.edu.
- Am J Emerg Med. 2024 Jul 1; 81: 127128127-128.
AbstractExtended-release formulations of buprenorphine offer less frequent dosing, provide consistent medication delivery, and improve adherence for treatment of opioid use disorder (OUD). Although buprenorphine is a partial agonist with seemingly less precipitated withdrawal and easier initiation than full opioid agonists used for OUD, its use is not benign and understanding of the different extended-release formulations is necessary. We report a case of a patient that received a long-acting buprenorphine formulation (Sublocade®) administered subcutaneously that presented to the emergency department with tachycardia, hyperglycemia, elevated anion gap, and sustained nausea and vomiting refractory to pharmacotherapy requiring surgical removal of the buprenorphine depot for resolution of nausea and vomiting symptoms.Copyright © 2024 Elsevier Inc. All rights reserved.

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Surgical removal of extended-release buprenorphine depot due to adverse reactions.

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