• Chen Wang, Xiang Yan, Chao Gao, Simeng Liu, Di Bao, Di Zhang, Jia Jiang, and Anshi Wu.
• Department of Anesthesiology, Beijing Chaoyang Hospital, Capital Medical University, Gongrentiyuchang South Road No.8, Beijing, China. correspondingauthor@foxmail.com.
• J Clin Monit Comput. 2024 Dec 1; 38 (6): 137913861379-1386.

BackgroundPostoperative sore throat (POST) is a common complication following endotracheal tube removal, and effective preventive strategies remain elusive. This trial aimed to determine whether actively regulating intraoperative cuff pressure below the tracheal capillary perfusion pressure threshold could effectively reduce POST incidence in patients undergoing gynecological laparoscopic procedures.MethodsThis single-center, randomized controlled superiority trial allocated 60 patients scheduled for elective gynecological laparoscopic procedures into two groups: one designated for cuff pressure measurement and adjustment (CPMA) group, and a control group where only cuff pressure measurement was conducted without any subsequent adjustments. The primary outcome was POST incidence at rest within 24 h post-extubation. Secondary outcomes included cough, hoarseness, postoperative nausea and vomiting (PONV) incidence, and post-extubation pain severity.ResultsThe incidence of sore throat at rest within 24 h after extubation in the CPMA group was lower than in the control group, meeting the criteria for statistically significant superiority based on a one-sided test (3.3% vs. 26.7%, P < 0.025). No statistically significant differences were observed in cough, hoarseness, or pain scores within 24 h post-extubation between the two groups. However, the CPMA group had a higher incidence of PONV compared to the control group. Additionally, the control group reported higher sore throat severity scores within 24 h post-extubation.ConclusionsContinuous monitoring and maintenance of tracheal tube cuff pressure at 18 mmHg were superior to merely monitoring without adjustment, effectively reducing the incidence of POST during quiet within 24 h after tracheal tube removal in gynecological laparoscopic surgery patients.Trial RegistrationThe study was registered at www.chictr.org.cn (ChiCTR2200064792) on 18/10/2022.© 2024. The Author(s), under exclusive licence to Springer Nature B.V.

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