• J. Korean Med. Sci. · Apr 2010

    Case Reports

    Cytomegalovirus ventriculoencephalitis after unrelated double cord blood stem cell transplantation with an alemtuzumab-containing preparative regimen for Philadelphia-positive acute lymphoblastic leukemia.

    • Seok Lee, Si-Hyun Kim, Su-Mi Choi, Dong-Gun Lee, Sung-Yong Kim, Jong-Wook Lee, Woo-Sung Min, Wan-Shik Shin, and Chun-Choo Kim.
    • Department of Hematology, Catholic Hematopoietic Stem Cell Transplantation Center, College of Medicine, The Catholic University of Korea, Seoul, Korea. leeseok@catholic.ac.kr
    • J. Korean Med. Sci. 2010 Apr 1; 25 (4): 630633630-3.

    AbstractDespite the prophylaxis and preemptive strategies using potent antiviral agents, cytomegalovirus (CMV) remains a major infectious cause of morbidity and mortality in allogeneic stem cell transplantation (SCT) recipients. Delayed immune reconstitution after SCT, such as cord blood and T-cell depleted SCT with the use of alemtuzumab, has been associated with an increased frequency of CMV disease as well as CMV reactivation. CMV disease involving central nervous system is an unusual presentation in the setting of SCT. We report a case of CMV ventriculoencephalitis after unrelated double cord blood SCT with an alemtuzumab-containing preparative regimen for Philadelphia-positive acute lymphoblastic leukemia.

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