• Evan L Barrios, Jaimar C Rincon, Micah Willis, Valerie E Polcz, Jack R Leary, Dijoia B Darden, Jeremy A Balch, Shawn D Larson, Tyler J Loftus, Alicia M Mohr, Shannon Wallet, Maigan A Brusko, Leandro Balzano-Nogueira, Guoshuai Cai, Ashish Sharma, Gilbert R Upchurch, Michael P Kladde, Clayton E Mathews, Robert Maile, Lyle L Moldawer, Rhonda Bacher, and Philip A Efron.
• Sepsis and Critical Illness Research Center, Department of Surgery, College of Medicine, Gainesville, Florida.
• Shock. 2024 Aug 1; 62 (2): 208216208-216.

AbstractPostsepsis early mortality is being replaced by survivors who experience either a rapid recovery and favorable hospital discharge or the development of chronic critical illness with suboptimal outcomes. The underlying immunological response that determines these clinical trajectories remains poorly defined at the transcriptomic level. As classical and nonclassical monocytes are key leukocytes in both the innate and adaptive immune systems, we sought to delineate the transcriptomic response of these cell types. Using single-cell RNA sequencing and pathway analyses, we identified gene expression patterns between these two groups that are consistent with differences in TNF-α production based on clinical outcome. This may provide therapeutic targets for those at risk for chronic critical illness in order to improve their phenotype/endotype, morbidity, and long-term mortality.Copyright © 2024 by the Shock Society.

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